11 research outputs found
Effector and memory CD4+ and CD8+ T cells in the chronic infection process.
T cell memory in comparison with B cell memory is not well understood. This review focuses on CD8+ and CD4+ memory T cells. In this article we try to define memory cells and also present models of memory T cells formation. We would also like to delineate their differentiation into distinct subsets. Long-lived memory T cells consist in two main subsets: TCM and TEM. Recent studies have shown that not all cells considered to be memory cells differentiate into TCM and TEM, but a small proportion of theses cells exhibit naive cells phenotype. Memory T cells constitute a heterogeneous population of cells. In this study we lay stress on characteristic of main memory T cells subsets and their alleged participation in immune response upon reexposure to the Ag
The inflammatory reaction during chronic venous disease of lower limbs.
Chronic venous disease (CVD) is an insufficiency of distal veins caused by their partial or total obstruction, endothelial distension and functional disorders. Chronic venous disease of lower limbs is common problem and affects millions of people. In this article we suggest that inflammatory process is involved in the structural remodeling in venous valves and in the venous wall, leading to valvular incompetence and the development of varicose veins
Evaluation of the memory CD4+ and CD8+ T cells homeostasis during chronic venous disease of lower limbs.
More and more is known about the role of venous wall abnormalities and valvular incompetence in the development of chronic venous disorders (CVD). Unfortunately detailed mechanisms of CVD pathophysiology are not well understood. Recent studies focus on involvement of the inflammatory process in the structural remodeling of venous valves and venous wall. The aim of this study is to investigate and to document the memory T cells homeostasis in CVD patients. In this study we present lymphocytic changes in blood from varicose veins in terms of total CD4+ and CD8+ T cells and their particular subsets of memory T cells: TN, TCM and TEM. Results suggest that immunological memory may be involved in the CVD development
Effector and memory CD4+ and CD8+ T cells in the chronic infection process.
T cell memory in comparison with B cell memory is not well understood. This review focuses on CD8+ and CD4+ memory T cells. In this article we try to define memory cells and also present models of memory T cells formation. We would also like to delineate their differentiation into distinct subsets. Long-lived memory T cells consist in two main subsets: TCM and TEM. Recent studies have shown that not all cells considered to be memory cells differentiate into TCM and TEM, but a small proportion of theses cells exhibit naive cells phenotype. Memory T cells constitute a heterogeneous population of cells. In this study we lay stress on characteristic of main memory T cells subsets and their alleged participation in immune response upon reexposure to the Ag
Evaluation of the memory CD4+ and CD8+ T cells homeostasis during chronic venous disease of lower limbs.
More and more is known about the role of venous wall abnormalities and valvular incompetence in the development of chronic venous disorders (CVD). Unfortunately detailed mechanisms of CVD pathophysiology are not well understood. Recent studies focus on involvement of the inflammatory process in the structural remodeling of venous valves and venous wall. The aim of this study is to investigate and to document the memory T cells homeostasis in CVD patients. In this study we present lymphocytic changes in blood from varicose veins in terms of total CD4+ and CD8+ T cells and their particular subsets of memory T cells: TN, TCM and TEM. Results suggest that immunological memory may be involved in the CVD development
Combination of LC–MS- and GC–MS-based Metabolomics to Study the Effect of Ozonated Autohemotherapy on Human Blood
Ozonated autohemotherapy (O<sub>3</sub>-AHT) is a medical
approach
during which blood obtained from the patient is ozonated and injected
back into the body. Despite an increasing number of evidence that
O<sub>3</sub>-AHT is safe, this type of therapy remains controversial.
To extend knowledge about the changes in blood evoked by O<sub>3</sub>-AHT, LC–MS- and GC–MS-based metabolic fingerprinting
was used to compare plasma samples obtained from blood before and
after the treatment with potentially therapeutic concentrations of
ozone. The procedure was performed in PVC bags utilized for blood
storage to study also possible interactions between ozone and plastic.
By use of GC–MS, an increase in lactic acid and pyruvic acid
was observed, which indicated an increased rate of glycolysis. With
LC–MS, changes in plasma antioxidants were observed. Moreover,
concentrations of lipid oxidation products (LOP) and lysophospholipids
were increased after ozone treatment. This is the first report of
increased LOPs metabolites after ozonation of blood. Seven metabolites
detected by LC–QTOF-MS only in ozonated samples could be considered
as novel biomarkers of oxidative stress. Several plasticizers have
been detected by both techniques in blood stored in PVC bags. PVC
is known to be an ozone resistant material, but ozonation of blood
in PVC bags stimulates leaching of plasticizers into the blood